Edited by
Guy-Franck Richard, Institut Pasteur, France.
ISBN : 9781789451191
Publication Date : January 2024
Hardcover 390 pp
165.00 USD
Co-publisher
The genome of a living being is composed of DNA sequences with diverse origins. Beyond single-copy genes, whose product has a biological function that can be inferred by experimentation, certain DNA sequences, present in a large number of copies, escape the most refined approaches aimed at elucidating their precise role.
The existence of what 20th century geneticists had already perceived (and wrongly described as “junk DNA”!) was confirmed by the sequencing of the first complex genomes, including that of Homo sapiens. A large part of what defines a living thing is not unique, but repeated, sometimes a very large number of times, increasing in complexity with successive duplications and multiplication.
Understanding and defining the many functions of this myriad of repeated sequences, as well as their evolution through natural selection, has become one of the major challenges for 21st century genomics.
1. Whole-Genome Duplications, a Source of Redundancy at the Entire-Genome Scale, Elise Parey and Camille Berthelot.
2. Segmental Duplications and CNVs: Adaptive Potential of Structural Polymorphism, Patricia Balaresque and Franklin Delehelle.
3. Transposable Elements: Parasites that Shape Genome Evolution, Amandine Bonnet, Karine Casier, Clément Carré, Laure Teysset, and Pascale Lesage.
4. Insights Into the Evolutionary Diversity of Centromeres, Nuria Cortes-Silva, Aruni P. Senaratne, and Ines A. Drinnenberg.
5. Evolution and Functions of Telomeres, Arturo Londoño-Vallejo.
6. G-quadruplexes: Structure, Detection and Functions, Emilia Puis Lombardi.
7. Satellite DNA, Microsatellites and Minisatellites, Wilhelm Vaysse-Zinkhöfer and Guy-Franck Richard.
8. CRISPR-Cas: An Adaptive Immune System, Marie Touchon.
Guy-Franck Richard is a research director at Institut Pasteur, France. He also leads a team within the CNRS unit Génétique des génomes. His research focuses on the stability and evolution of repeated DNA sequences in eukaryotic organisms.
