General

Authors

Search


Committee login



 
 

 


 

 

Forthcoming

Small thumbnail

Reliability Investigation of LED Devices for Public Light Applications

Durability, Robustness and Reliability of Photonic Devices Set

Small thumbnail

Aerospace Actuators 2

Signal-by-Wire and Power-by-Wire

Small thumbnail

Flash Memory Integration

Performance and Energy Considerations

Small thumbnail

Mechanics of Aeronautical Solids, Materials and Structures

Small thumbnail

Engineering Investment Process

Making Value Creation Repeatable

Small thumbnail

Space Strategy

Small thumbnail

Distributed Systems

Concurrency and Consistency

Small thumbnail

Fatigue of Textile and Short Fiber Reinforced Composites

Durability and Ageing of Organic Composite Materials Set Volume 1

Small thumbnail

Management of the Effects of Coastal Storms

Policy, Scientific and Historical Perspectives

Small thumbnail

Computational Color Science

Variational Retinex-like Methods

Small thumbnail

Live Cell Assays

From Research to Health and Regulatory Applications

Christophe Furger, Pierre et Marie Curie University, France

ISBN: 9781848218581

Publication Date: July 2016   Hardback   280 pp.

125.00 USD


Add to cart

eBooks


Ebook Ebook

Description

Cell assays include all methods of measurements on living cells. Confined for a long time to research laboratories, these emerging methods have, in recent years, found industrial applications that are increasingly varied and, from now on, regulatory.
Based on the recent explosion of knowledge in cell biology, the measurement of living cells represents a new class of industry-oriented research tests, the applications of which continue to multiply (pharmaceuticals, cosmetics, environment, etc.). Cellular tests are now being positioned as new tools at the interface between chemical methods, which are often obsolete and not very informative, and methods using animal models, which are expensive, do not fit with human data and are widely discussed from an ethical perspective. Finally, the development of cell assays is currently being strengthened by their being put into regulatory application, particularly in Europe through the REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) and cosmetic directives. This book is the first summary ever written.

Contents

1. Principles and Position.
2. History and State of the Art.
3. Cell Models and Technologies.
4. Loss of Cell Homeostasis: Applications in Toxicity Measurement.
5. The Replacement of Animal Testing: A Driving Force in Live Cell Assay Development.
6. Regulatory Applications and Validation.
7. Cell Signaling: At the Heart of Functional Assays for Industrial Purposes.
8. Applications in New Drug Discovery.
9. Impact on Health and the Environment.
10. Outlook.

About the Authors

Christophe Furger is a cell biologist, Doctor of Pierre et Marie Curie University (Sorbonne Universities, Paris, France) and Director of Research and Development at L.E.D. He has been working since 1995 on the conception of cell assays. He currently heads a public/private research program in toxicity at the LAAS/CNRS lab (Toulouse, France).

Downloads

DownloadTable of Contents - PDF File - 425 Kb

































0.02654 s.